{"id":2517,"date":"2022-09-22T17:22:12","date_gmt":"2022-09-22T17:22:12","guid":{"rendered":"https:\/\/mazzistudios.com\/clientsite-pls\/?p=2517"},"modified":"2023-09-23T17:38:40","modified_gmt":"2023-09-23T17:38:40","slug":"resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic","status":"publish","type":"post","link":"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/","title":{"rendered":"Resilient clinical trial infrastructure in response to the COVID-19 pandemic"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_column_text]\n<h3><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1909 size-medium\" src=\"https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2022\/09\/logo_astmh-300x168.jpg\" alt=\"ASTMH Logo\" width=\"300\" height=\"168\" srcset=\"https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2022\/09\/logo_astmh-300x168.jpg 300w, https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2022\/09\/logo_astmh-768x431.jpg 768w, https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2022\/09\/logo_astmh.jpg 999w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Abstract<\/h3>\n<p>In response to the COVID-19 pandemic, clinical research groups across the world developed trial protocols to evaluate the safety and efficacy of treatments for COVID-19. Despite this initial enthusiasm, only a small portion of these protocols were implemented. Of those implemented, a fraction successfully recruited their target sample size to analyze and disseminate findings. More than a year and a half into the COVID-19 pandemic, only a few clinical trials evaluating treatments for COVID-19 have generated new evidence. Productive randomized platform clinical trials evaluating COVID-19 treatments may attribute their success to intentional investments in developing resilient clinical trial infrastructures. Health system resiliency discourse provides a conceptual framework for characterizing attributes for withstanding shocks. This framework may also be useful for contextualizing the attributes of productive clinical trials evaluating COVID-19 therapies. We characterize the successful attributes and lessons learned in developing the TOGETHER Trial infrastructure using a health system resiliency framework. This framework may be considered by clinical trialists aiming to build resilient trial infrastructures capable of responding rapidly and efficiently to global health threats.[\/vc_column_text][divider line_type=&#8221;No Line&#8221; custom_height=&#8221;100&#8243;][nectar_cta btn_style=&#8221;underline&#8221; heading_tag=&#8221;h5&#8243; button_color=&#8221;default&#8221; text_color_hover=&#8221;#4ea585&#8243; button_border_thickness=&#8221;0px&#8221; link_type=&#8221;new_tab&#8221; alignment=&#8221;left&#8221; alignment_tablet=&#8221;default&#8221; alignment_phone=&#8221;default&#8221; display=&#8221;block&#8221; display_tablet=&#8221;inherit&#8221; display_phone=&#8221;inherit&#8221; icon_family=&#8221;fontawesome&#8221; link_text=&#8221;Read Full Article&#8221; url=&#8221;https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/2\/article-p389.xml&#8221; icon_fontawesome=&#8221;fa fa-long-arrow-right&#8221;][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>In 2020, clinical trial researchers developed protocols to evaluate the safety and effectiveness of potential treatments for COVID-19. Despite more than 3,000 trials registered, few have generated findings, with the exception of smaller randomized controlled trials.<\/p>\n","protected":false},"author":18,"featured_media":2519,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","inline_featured_image":false,"footnotes":""},"categories":[38],"tags":[77],"post-month-for-search":[57],"post-year-for-search":[45],"class_list":{"0":"post-2517","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-publications","8":"tag-astmh","9":"post-month-for-search-september","10":"post-year-for-search-45"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v18.1 (Yoast SEO v21.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Resilient clinical trial infrastructure in response to the COVID-19 pandemic | Purpose Life Sciences<\/title>\n<meta name=\"description\" content=\"In 2020, clinical trial researchers developed protocols to evaluate the safety and effectiveness of potential treatments for COVID-19.\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Resilient clinical trial infrastructure in response to the COVID-19 pandemic\" \/>\n<meta property=\"og:description\" content=\"In 2020, clinical trial researchers developed protocols to evaluate the safety and effectiveness of potential treatments for COVID-19.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/\" \/>\n<meta property=\"og:site_name\" content=\"Purpose Life Sciences\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-22T17:22:12+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-09-23T17:38:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2022\/09\/resilient_clinical_trial_infrastructure.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1456\" \/>\n\t<meta property=\"og:image:height\" content=\"816\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Purpose Life Sciences\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Purpose Life Sciences\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/\"},\"author\":{\"name\":\"Purpose Life Sciences\",\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/#\/schema\/person\/1f160552d27a87eb0ce41037e69653f4\"},\"headline\":\"Resilient clinical trial infrastructure in response to the COVID-19 pandemic\",\"datePublished\":\"2022-09-22T17:22:12+00:00\",\"dateModified\":\"2023-09-23T17:38:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/\"},\"wordCount\":415,\"publisher\":{\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/#organization\"},\"keywords\":[\"ASTMH\"],\"articleSection\":[\"Publications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/\",\"url\":\"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/\",\"name\":\"Resilient clinical trial infrastructure in response to the COVID-19 pandemic | Purpose Life Sciences\",\"isPartOf\":{\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/#website\"},\"datePublished\":\"2022-09-22T17:22:12+00:00\",\"dateModified\":\"2023-09-23T17:38:40+00:00\",\"description\":\"In 2020, clinical trial researchers developed protocols to evaluate the safety and effectiveness of potential treatments for COVID-19.\",\"breadcrumb\":{\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/mazzistudios.com\/clientsite-pls\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Resilient clinical trial infrastructure in response to the COVID-19 pandemic\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/#website\",\"url\":\"https:\/\/mazzistudios.com\/clientsite-pls\/\",\"name\":\"Purpose Life Sciences\",\"description\":\"Build a healthier world with innovative trials Platform Life Sciences redefines clinical trials by providing speed, adaptability, and global partnerships to evaluate life-saving therapeutics.\",\"publisher\":{\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/mazzistudios.com\/clientsite-pls\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/#organization\",\"name\":\"Purpose Life Sciences\",\"url\":\"https:\/\/mazzistudios.com\/clientsite-pls\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2023\/08\/Black-Purpose-Life-Sciences-Logo.png\",\"contentUrl\":\"https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2023\/08\/Black-Purpose-Life-Sciences-Logo.png\",\"width\":2428,\"height\":676,\"caption\":\"Purpose Life Sciences\"},\"image\":{\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.linkedin.com\/company\/purpose-life-sciences\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/#\/schema\/person\/1f160552d27a87eb0ce41037e69653f4\",\"name\":\"Purpose Life Sciences\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/mazzistudios.com\/clientsite-pls\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/d0eb1704f8653edaede33e15637cbbbe2e2ee7a98d22920aea8d3b75bd31efa9?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/d0eb1704f8653edaede33e15637cbbbe2e2ee7a98d22920aea8d3b75bd31efa9?s=96&d=mm&r=g\",\"caption\":\"Purpose Life Sciences\"},\"url\":\"https:\/\/mazzistudios.com\/clientsite-pls\/author\/lpancoplatformlifesciences-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Resilient clinical trial infrastructure in response to the COVID-19 pandemic | Purpose Life Sciences","description":"In 2020, clinical trial researchers developed protocols to evaluate the safety and effectiveness of potential treatments for COVID-19.","robots":{"index":"noindex","follow":"follow"},"og_locale":"en_US","og_type":"article","og_title":"Resilient clinical trial infrastructure in response to the COVID-19 pandemic","og_description":"In 2020, clinical trial researchers developed protocols to evaluate the safety and effectiveness of potential treatments for COVID-19.","og_url":"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/","og_site_name":"Purpose Life Sciences","article_published_time":"2022-09-22T17:22:12+00:00","article_modified_time":"2023-09-23T17:38:40+00:00","og_image":[{"width":1456,"height":816,"url":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2022\/09\/resilient_clinical_trial_infrastructure.jpg","type":"image\/jpeg"}],"author":"Purpose Life Sciences","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Purpose Life Sciences","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/#article","isPartOf":{"@id":"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/"},"author":{"name":"Purpose Life Sciences","@id":"https:\/\/mazzistudios.com\/clientsite-pls\/#\/schema\/person\/1f160552d27a87eb0ce41037e69653f4"},"headline":"Resilient clinical trial infrastructure in response to the COVID-19 pandemic","datePublished":"2022-09-22T17:22:12+00:00","dateModified":"2023-09-23T17:38:40+00:00","mainEntityOfPage":{"@id":"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/"},"wordCount":415,"publisher":{"@id":"https:\/\/mazzistudios.com\/clientsite-pls\/#organization"},"keywords":["ASTMH"],"articleSection":["Publications"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/","url":"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/","name":"Resilient clinical trial infrastructure in response to the COVID-19 pandemic | Purpose Life Sciences","isPartOf":{"@id":"https:\/\/mazzistudios.com\/clientsite-pls\/#website"},"datePublished":"2022-09-22T17:22:12+00:00","dateModified":"2023-09-23T17:38:40+00:00","description":"In 2020, clinical trial researchers developed protocols to evaluate the safety and effectiveness of potential treatments for COVID-19.","breadcrumb":{"@id":"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mazzistudios.com\/clientsite-pls\/resilient-clinical-trial-infrastructure-in-response-to-the-covid-19-pandemic\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mazzistudios.com\/clientsite-pls\/"},{"@type":"ListItem","position":2,"name":"Resilient clinical trial infrastructure in response to the COVID-19 pandemic"}]},{"@type":"WebSite","@id":"https:\/\/mazzistudios.com\/clientsite-pls\/#website","url":"https:\/\/mazzistudios.com\/clientsite-pls\/","name":"Purpose Life Sciences","description":"Build a healthier world with innovative trials Platform Life Sciences redefines clinical trials by providing speed, adaptability, and global partnerships to evaluate life-saving therapeutics.","publisher":{"@id":"https:\/\/mazzistudios.com\/clientsite-pls\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mazzistudios.com\/clientsite-pls\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/mazzistudios.com\/clientsite-pls\/#organization","name":"Purpose Life Sciences","url":"https:\/\/mazzistudios.com\/clientsite-pls\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/mazzistudios.com\/clientsite-pls\/#\/schema\/logo\/image\/","url":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2023\/08\/Black-Purpose-Life-Sciences-Logo.png","contentUrl":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2023\/08\/Black-Purpose-Life-Sciences-Logo.png","width":2428,"height":676,"caption":"Purpose Life Sciences"},"image":{"@id":"https:\/\/mazzistudios.com\/clientsite-pls\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.linkedin.com\/company\/purpose-life-sciences\/"]},{"@type":"Person","@id":"https:\/\/mazzistudios.com\/clientsite-pls\/#\/schema\/person\/1f160552d27a87eb0ce41037e69653f4","name":"Purpose Life Sciences","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/mazzistudios.com\/clientsite-pls\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/d0eb1704f8653edaede33e15637cbbbe2e2ee7a98d22920aea8d3b75bd31efa9?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/d0eb1704f8653edaede33e15637cbbbe2e2ee7a98d22920aea8d3b75bd31efa9?s=96&d=mm&r=g","caption":"Purpose Life Sciences"},"url":"https:\/\/mazzistudios.com\/clientsite-pls\/author\/lpancoplatformlifesciences-com\/"}]}},"_links":{"self":[{"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/posts\/2517","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/comments?post=2517"}],"version-history":[{"count":0,"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/posts\/2517\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/media\/2519"}],"wp:attachment":[{"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/media?parent=2517"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/categories?post=2517"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/tags?post=2517"},{"taxonomy":"post-month-for-search","embeddable":true,"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/post-month-for-search?post=2517"},{"taxonomy":"post-year-for-search","embeddable":true,"href":"https:\/\/mazzistudios.com\/clientsite-pls\/wp-json\/wp\/v2\/post-year-for-search?post=2517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}