{"id":2277,"date":"2023-05-02T12:33:57","date_gmt":"2023-05-02T12:33:57","guid":{"rendered":"https:\/\/mazzistudios.com\/clientsite-pls\/?p=2277"},"modified":"2023-09-13T13:16:21","modified_gmt":"2023-09-13T13:16:21","slug":"long-acting-antiretrovirals-and-hiv-treatment-adherence","status":"publish","type":"post","link":"https:\/\/mazzistudios.com\/clientsite-pls\/long-acting-antiretrovirals-and-hiv-treatment-adherence\/","title":{"rendered":"Long-acting antiretrovirals and HIV treatment adherence"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_column_text]\n<h3><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-1714\" src=\"https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2022\/12\/lancet-300x168.jpeg\" alt=\"The Lancet - Logo\" width=\"300\" height=\"168\" srcset=\"https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2022\/12\/lancet-300x168.jpeg 300w, https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2022\/12\/lancet-768x431.jpeg 768w, https:\/\/mazzistudios.com\/clientsite-pls\/wp-content\/uploads\/2022\/12\/lancet.jpeg 999w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Summary<\/h3>\n<p>Intramuscular injection of long-acting cabotegravir and rilpivirine is a novel, long-acting antiretroviral therapy (ART) combination approved for use as a fully suppressive regimen for people living with HIV. Long-acting cabotegravir with rilpivirine ART has reduced required dosing frequency from once daily to once every month or every 2 months injections. This new era of long-acting ART, which includes other antiretrovirals and formulations in various stages of clinical development, holds tremendous promise to change the standard of HIV treatment. Although long-acting ART has high potential to be revolutionary in the landscape of HIV care, prevention, and treatment cascade, more data are needed to substantiate its efficacy and cost-effectiveness among patients at risk of non-adherence and across age groups, pregnancy, and post partum. Advocacy efforts and policy changes to optimise a sustained, high-quality, equitable reach of long-acting ART, especially in low-income and middle-income countries where most people living with HIV reside, are needed to realise the full benefits of long-acting ART.<\/p>\n<p>Authors:<\/p>\n<ul class=\"rlist loa inline-bullet-list \" data-number-of-author=\"6\" data-ol-has-click-handler=\"\">\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Prof Jean B Nachega, PhD\u00a0<i class=\"icon-gizmo-person faded\" aria-hidden=\"true\"><\/i>\u00a0<sup>\u2020<\/sup><\/div>\n<\/li>\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Prof Kimberly K Scarsi, PharmD\u00a0<sup>\u2020<\/sup><\/div>\n<\/li>\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Prof Monica Gandhi, MD<\/div>\n<\/li>\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Rachel K Scott, MD<\/div>\n<\/li>\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Lynne M Mofenson, MD<\/div>\n<\/li>\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Prof Moherndran Archary, PhD<\/div>\n<\/li>\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Prof Sharon Nachman, MD<\/div>\n<\/li>\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Prof Eric Decloedt, PhD<\/div>\n<\/li>\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Prof Elvin H Geng, MD<\/div>\n<\/li>\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Lindsay Wilson, MSc<\/div>\n<\/li>\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Angeli Rawat, PhD<\/div>\n<\/li>\n<li class=\"loa__item author\">\n<div class=\"dropBlock article-header__info\">Prof John W Mellors, MD<\/div>\n<\/li>\n<\/ul>\n[\/vc_column_text][divider line_type=&#8221;No Line&#8221; custom_height=&#8221;100&#8243;][nectar_cta btn_style=&#8221;underline&#8221; heading_tag=&#8221;h5&#8243; button_color=&#8221;default&#8221; text_color_hover=&#8221;#4ea585&#8243; button_border_thickness=&#8221;0px&#8221; link_type=&#8221;new_tab&#8221; alignment=&#8221;left&#8221; alignment_tablet=&#8221;default&#8221; alignment_phone=&#8221;default&#8221; display=&#8221;block&#8221; display_tablet=&#8221;inherit&#8221; display_phone=&#8221;inherit&#8221; icon_family=&#8221;fontawesome&#8221; link_text=&#8221;Read Full Article&#8221; url=&#8221;https:\/\/www.thelancet.com\/journals\/lanhiv\/article\/PIIS2352-3018(23)00051-6\/fulltext&#8221; icon_fontawesome=&#8221;fa fa-long-arrow-right&#8221;][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>Intramuscular injection of long-acting cabotegravir and rilpivirine is a novel, long-acting antiretroviral therapy (ART) combination approved for use as a fully suppressive regimen for people living with HIV.<\/p>\n","protected":false},"author":17,"featured_media":2278,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","inline_featured_image":false,"footnotes":""},"categories":[38],"tags":[62],"post-month-for-search":[53],"post-year-for-search":[61],"class_list":{"0":"post-2277","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-publications","8":"tag-the-lancet","9":"post-month-for-search-may","10":"post-year-for-search-61"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v18.1 (Yoast SEO v21.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Long-acting antiretrovirals and HIV treatment adherence | Purpose Life Sciences<\/title>\n<meta name=\"description\" content=\"The massive scale-up of HIV treatment and prevention over the past two decades has resulted in important reductions in new infections and 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